Basic Information
VIS ID
TVIS10011137
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2629
Orient
+
Integrated sequence
GAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTG| |CAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATT
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
114622360/114301196 (Hg38)
End
114622360/114301196 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
HDAC2-AS2 ; HS3ST5
miRNAs that regulate target gene
hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-3120-3p ; hsa-mir-4668-5p ; hsa-mir-539-5p ; hsa-mir-7151-5p ; hsa-mir-4668-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-10398/Upstream/7516976; hsa-mir-1202/Downstream/4767851;
Nearest TSS
ENST00000381078/Upstream/19384; ENST00000517965/Downstream/41849;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/329593, chr6-CpG: 127/Downstream/40968
Nearby gene
HS3ST5(-238319) ; FRK(+1640333) ;
Upstream sequence
GTTTGTGACTGGAGTGCTACCTGAGTAAATTATCATGATTACATGAAAAGCAATTAAGAGAAGAAGGTCAAAGGACCAACCTCTAATCACTAAGTTTGGT
Downstream sequence
aaaaaATAATAAGCAGGTTTCATCAAAGGTCAATTCTGTGCAAAATGTATGTTATTAATAATAAGTTCATTTTTAGTTCATCTTTGTTATTTTTCTAGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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