Basic Information
VIS ID
TVIS10011140
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2963
Orient
+
Integrated sequence
TTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAG| |GACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGG
Host Sequence
Chromosome
chr6
Cytoband
p23
Reference genome
GRCh37/hg19
Start
15011720/15011489 (Hg38)
End
15011720/15011489 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6A
Nearest miRNA
hsa-mir-3691/Upstream/4571695; hsa-mir-10398/Downstream/1130067;
Nearest TSS
ENST00000381078/Upstream/411799; ENST00000474854/Downstream/10475;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/799976, chr6-CpG: 113/Downstream/233157
Nearby gene
CD83(-874572) ; JARID2(+234486) ;
Upstream sequence
gatctccttaaatcatacttactcttcaaatgaaaataataataaggtcatatttgtgcctaacataatacaactatcctttatgtaattaaaaatgcac
Downstream sequence
catgtcttttgcaggaacatggatagagttggaagctattattcttagcaaactaatacaggaacagaaaaccaaatatcacatgttctcatttataagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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