Basic Information
VIS ID
TVIS10011144
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
41383689/41415951 (Hg38)
End
41383689/41415951 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/2341570; hsa-mir-10398/Downstream/182772;
Nearest TSS
ENST00000381078/Upstream/80100; ENST00000416951/Downstream/86493;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/6522, chr6-CpG: 99/Downstream/11540
Nearby gene
NCR2(-65064) ; FOXP4(+130475) ;
Upstream sequence
gagaaaaggaaggaaggaagtaaggaaggaaAAAATCAGGTAAAACCTTAGATTTGTCACAGTTCTTACCAATTTTTATGATAAGGATAGCATGCTGATA
Downstream sequence
ATCAGAgtgtgtgtgtgtgtgtgtgtgtgtgtgtgagagagagagagagagagagagaATATACAAGTGAGATGAGGGGAAGACTGGGAAACCACGGGGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate