Basic Information
VIS ID
TVIS10011146
Fusion event
HBV-LOC105377865 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1838
Orient
+
Integrated sequence
GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCT| |AATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACT
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
78872263/78162546 (Hg38)
End
78872263/78162546 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105377865
Nearest miRNA
hsa-mir-10398/Upstream/2734073; hsa-mir-10524/Downstream/376717;
Nearest TSS
ENST00000381078/Upstream/471888; ENST00000607739/Downstream/443490;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/511919, chr6-CpG: 46/Downstream/704895
Nearby gene
HTR1B(-699143) ; IRAK1BP1(+704926) ;
Upstream sequence
GTTTGTGACTGGAGTGCTACCTGAGTAAATTATCATGATTACATGAAAAGCAATTAAGAGAAGAAGGTCAAAGGACCAACCTCTAATCACTAAGTTTGGT
Downstream sequence
GATGGTAATGTAATTGTGTGGAACCACATCAAATGGGGATGATTAAAACTTTCCTGTCTCTTCTGCACATGGGCAGCTTTTTTTTTTCAAATCCATTTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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