Basic Information
VIS ID
TVIS10011149
Fusion event
HBV-LOC105375392 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2907
Orient
-
Integrated sequence
CATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGG| |ATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGG
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
90970221/91340906 (Hg38)
End
90970221/91340906 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7E
Target gene
LOC105375392
Nearest miRNA
hsa-mir-10525/Upstream/15425637; hsa-mir-10399/Downstream/863109;
Nearest TSS
ENST00000635602/Upstream/28466; ENST00000438114/Downstream/215942;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/73538, chr7-CpG: 35/Downstream/539777
Nearby gene
FZD1(-72089) ; MTERF(+531800) ;
Upstream sequence
ATAGTAAAATGTGTTCAATTACTCACCTCCTCAAACTATGAGCATACATAATTTTGAGTAAAACAAAAAGTAAAATTTTTAAATGTCATGTATCACTACC
Downstream sequence
ggaGGCCATAGAGTGTTCTGTACtggattgaattttgtcccctcaaaagacgtgttcaaaccttaacccctagaatctgtgaatgcgaccatatttggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate