Basic Information
VIS ID
TVIS10011154
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1776
Orient
-
Integrated sequence
CAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACT| |AGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCA
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
80256446/79344211 (Hg38)
End
80256446/79344211 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/11937; hsa-mir-10400/Downstream/897178;
Nearest TSS
ENST00000518652/Upstream/46494; ENST00000518491/Downstream/266603;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/539043, chr8-CpG: 38/Downstream/267529
Nearby gene
IL7(-538688) ; STMN2(+266603) ;
Upstream sequence
ctacagaggagggacctgaccattgcaagaaaaagaaacaaacagaaagcaacaacaacagcatcaacaaaaaaagttcccacaaaaaccccatccaagg
Downstream sequence
CTTTCCACGTCATCATGAATCAAAAAATCTCTGAATTATATTTGATTCCTTCATCTACTTTATGCCTACATCTAATTACCTAAGACATCTTATTGATTGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate