Basic Information
VIS ID
TVIS10011162
Fusion event
HBV-chrY integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2312
Orient
-
Integrated sequence
ACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGC| |CCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCG
Host Sequence
Chromosome
chrY
Cytoband
q11.223
Reference genome
GRCh37/hg19
Start
22470123/20308237 (Hg38)
End
22470123/20308237 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/6828971;
Nearest TSS
ENST00000430575/Upstream/563298; ENST00000465253/Downstream/210170;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/740567, chrY-CpG: 16/Downstream/267702
Nearby gene
KDM5D(-563298) ; TTTY10(+157431) ;
Upstream sequence
ttccataccattccatcccattccattccattccattccattgcattccattccattccattccattgcactgcactccattccattacattctactcta
Downstream sequence
cagtttcttccttctggcaggttcatggtcttgctcacttcaagaataaaactgtagaactttacggttagtgttacagcactgaaagatgttatgtcca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate