Basic Information
VIS ID
TVIS10011171
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
46
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAG| |GCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCC
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
195244486/195275356 (Hg38)
End
195244486/195275356 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1K
Nearest miRNA
hsa-mir-101-1/Upstream/2138773; hsa-mir-1182/Downstream/1307057;
Nearest TSS
ENST00000473358/Upstream/924413; ENST00000496761/Downstream/785717;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2153262, chr1-CpG: 24/Downstream/1333222
Nearby gene
KCNT2(+950427) ;
Upstream sequence
CATGAAATTTTAAATCAGCTATGCTTTAAGATAGAAAACCATGAGGTCCTGTGAGAGGGTAATATTATCTTAGAGAAAAGTTTTAGTGAGGGCTCTTCTG
Downstream sequence
AAGTGAAATTTACTCTGAGAATCTGTAGAGGACATCTCTTATTATTGAGGAAAGGGAGGAATTACGGTCCTCCTTCAGCTCAGAGTAAATGGAGTGTGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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