VISDB Viral Integration Site DataBase

VIS ID

TVIS10011176

Fusion event

HBV-OCA2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

550

Orient

+

Integrated sequence

GACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCT| |CTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTG

Chromosome

chr15

Cytoband

q12

Reference genome

Start

End

28031185/27786039 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-6515-5p ; hsa-mir-6869-5p ; hsa-mir-5706 ; hsa-mir-526b-5p ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6783-5p

Nearest miRNA

hsa-mir-1268a/Upstream/1937214; hsa-mir-10393/Downstream/640452;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/14530, chr15-CpG: 42/Downstream/19065

Upstream sequence

gtgaatgcacctcaaaagcattacgctaagtgaaagaagcccaacaccaaaggtcatatattatatgattctatttatttgaaatatctggaataggaaa

Downstream sequence

atctataaatacagaTATACAtctaactttgtcttcatgtatgttgaaatccaattgttccagcaccgtttgtttaaatgactatccttttccaattgaa