Basic Information
VIS ID
TVIS10011180
Fusion event
HBV-LOC105371597 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2162
Orient
+
Integrated sequence
CACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAG| |TTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTG
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
21811071/22284465 (Hg38)
End
21811071/22284465 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105371597
Nearest miRNA
hsa-mir-1180/Upstream/2939891; hsa-mir-10226/Downstream/5009445;
Nearest TSS
ENST00000595228/Upstream/18040; ENST00000577956/Downstream/1117;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/66944, chr17-CpG: 27/Downstream/150909
Nearby gene
LINC02693(-356130) ; FAM27E5(+14299) ;
Upstream sequence
AAGTGCTTCTATGAATGGGATAAAATATTTCATTTTTTTCAGCATTCCACATTTTTGACTCATTGACTCAGCTAAACCACATAAATCTTCACTTTTTTCT
Downstream sequence
ATTTTATATATCATAATGCCTATCTTTCAGCTGTGAAAAATTATCAACTATATTTGTTTATTAACTTTGGGAATATGAAATTCAGATCATGATCTTCTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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