Basic Information
VIS ID
TVIS10011183
Fusion event
HBV-LOC107985325 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
562
Orient
+
Integrated sequence
ATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCT| |CCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCG
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
55522530/55011162 (Hg38)
End
55522530/55011162 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LOC107985325
Nearest miRNA
hsa-let-7e/Upstream/365779; hsa-mir-10394/Downstream/112063;
Nearest TSS
ENST00000633603/Upstream/4957; ENST00000586961/Downstream/7657;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/27995, chr19-CpG: 85/Downstream/21687
Nearby gene
NLRP2(-10020) ; GP6(+2545) ;
Upstream sequence
agtgctgttttctggctatttggaactgctgtccagtttgtattggggtcaagcggcattgcagaagaaaataaggcatttaggttttaggtcaggtgtg
Downstream sequence
agttgaagaggttttaagtttttgagaacacaggccaagggagagaaggaggaggaatggagggtggaaggttgcccatagtgaaggaggcaagcctaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate