Basic Information
VIS ID
TVIS10011185
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
537
Orient
+
Integrated sequence
GTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACT| |GCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAAT
Host Sequence
Chromosome
chr2
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
31653109/31430243 (Hg38)
End
31653109/31430243 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1301/Upstream/3433794; hsa-mir-10b/Downstream/1101910;
Nearest TSS
ENST00000437798/Upstream/15528; ENST00000435713/Downstream/96699;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/195456, chr2-CpG: 99/Downstream/149980
Nearby gene
XDH(-15498) ; SRD5A2(+96547) ;
Upstream sequence
TGGACAAATGAATCCATAAGGAAGGGCTGAGAAAGGGACAGGTGGGAAAAGCGGTCTCGGTGAAGATGAAGGAGGAAGTCAGAAAGTAGTTCAAAAAAAC
Downstream sequence
CAATTCTAGCAGACGGAGGATGAGCCAGGCACTCCTGCCCACCTCTGTGGCCTTGTGGTTTCCTGTGGCATGATGCCAACTTAATTCTACACAAGCCAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate