Basic Information
VIS ID
TVIS10011188
Fusion event
HBV-LOC107986178 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2416
Orient
-
Integrated sequence
ATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGC| |GTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCT
Host Sequence
Chromosome
chr4
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
11721365/11719741 (Hg38)
End
11721365/11719741 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC107986178
Nearest miRNA
hsa-mir-3138/Upstream/350820; hsa-mir-12113/Downstream/63437;
Nearest TSS
ENST00000502981/Upstream/94027; ENST00000508998/Downstream/2696;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/290109, chr4-CpG: 97/Downstream/1764157
Nearby gene
HS3ST1(-290828) ; HSP90AB2P(+1613672) ;
Upstream sequence
tttaagcatcgactccctagttttatctaggcacatctagtgaatgattgcatttctaggctcccttggatctaggtttggctatgagactgttctactc
Downstream sequence
GACTGACTGTCGAGCTATGTATACACAAGCAGGCTGGCTAGTTGTGTGGTAGTCTTTCCAGAAAATCAGGGCAAGTGCGGTGGCATGGTTGACTGTTCAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate