VISDB Viral Integration Site DataBase

VIS ID

TVIS10011203

Fusion event

HBV-LYN integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

72

Orient

+

Integrated sequence

AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCC| |AGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACAT

Chromosome

chr8

Cytoband

q12.1

Reference genome

Start

End

56808182/55895623 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-222-3p ; hsa-mir-32-3p ; hsa-mir-4731-3p ; hsa-mir-4801 ; hsa-mir-548c-3p ; hsa-mir-205-5p ; hsa-mir-6513-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-4278 ; hsa-mir-625-5p ; hsa-mir-3148 ; hsa-mir-4668-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4330 ; hsa-mir-10b-3p ; hsa-mir-6732-5p ; hsa-mir-6805-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-628-5p ; hsa-mir-466 ; hsa-mir-221-3p ; hsa-mir-548v ; hsa-mir-187-5p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-122-5p ; hsa-mir-1304-3p ; hsa-mir-143-5p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4639-3p ; hsa-mir-504-3p ; hsa-mir-564 ; hsa-mir-5693 ; hsa-mir-5698 ; hsa-mir-6499-3p ; hsa-mir-6794-3p ; hsa-mir-891a-3p

Nearest miRNA

hsa-mir-124-1/Upstream/12999348; hsa-mir-10400/Downstream/5819165;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/14857, chr8-CpG: 69/Downstream/178374

Upstream sequence

gctgggagtggtggctcacatctgtaacctcagcactttgggaggccaaggtgggcagatcacttgaggtcaggagttcgagaacagcccggccaacatg

Downstream sequence

tacaaTTTTTTTTTTAAaggaattggcttctagtcaatgctttgtcaaataccagtcttgggacattagatgaagctccttcatctaatgtttttctaat