Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011205
Fusion event
HBV-RALYL integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
47
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGG| |CCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCT
Host Sequence
Chromosome
chr8
Cytoband
q21.2
Reference genome
Start
End
85533031/84620796 (Hg38)
Orient
+
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-12123/Upstream/4379323; hsa-mir-10400/Downstream/6584689;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/435784, chr8-CpG: 47/Downstream/486274
Upstream sequence
TTTAGAGAATAAAAACATTGGATTAGAAGTTTATATACAACATATTTGCCTCCATAAATAAGTGCAAATTCTGAAATTCAAAGCaaaaaattttttaaaa
Downstream sequence
agttttccttctaacagacaggaccctcagctgcaggtctgctggagtaccctgccgtgtgaggtgtcagtgtgcccctgctggggggtgcctcccagtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.