Basic Information
VIS ID
TVIS10011212
Fusion event
HBV-ADAMTSL4-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1820
Orient
+
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
150541300/150568824 (Hg38)
End
150541300/150568824 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
ADAMTSL4-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/16810; hsa-mir-1182/Downstream/976972;
Nearest TSS
ENST00000473358/Upstream/10570; ENST00000636087/Downstream/9953;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6999, chr1-CpG: 103/Downstream/10028
Nearby gene
ADAMTSL4(-7888) ; MCL1(+5727) ;
Upstream sequence
CTTAAAAGAGCAACTTTATTCAAACCAGGCCTGCCAATGCCAACTCCTTCAGTCTAGATCCAAAGATGGCTATGATCCTGAGATTGTGTGTTTAGGGTCA
Downstream sequence
CCACTTTAACATGATACAGGAAGCAATTGAGTCTTTTCTACTTCCTAAACACAGTCCATCCAGTTGTGTGTCATTTATACCCAGTCCAGACTTATTTAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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