Basic Information
VIS ID
TVIS10011223
Fusion event
HBV-FYB2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1796
Orient
-
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAAT| |TGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
GRCh37/hg19
Start
57203802/56738129 (Hg38)
End
57203802/56738129 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
FYB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1512406; hsa-mir-101-1/Downstream/2995098;
Nearest TSS
ENST00000473358/Upstream/482; ENST00000361249/Downstream/23884;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/92565, chr1-CpG: 222/Downstream/684162
Upstream sequence
AAACTAACAAACAACAGAACACATGACCCTCTTTTATTGACAAATTCAATGTACTGaacgtgtattgacagcctactatgtgtcaagcaccgtgctaatt
Downstream sequence
tatgcactattattttaatGGAAAAGCAAACAACATTCCAATGATCCATTCTCAATTCAGTTAGTTTGCTGGTGGCAATGTGATCATATTCAGTTAGTGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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