Basic Information
VIS ID
TVIS10011225
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1929
Orient
+
Integrated sequence
CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT| |GGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAG
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
68159612/67693929 (Hg38)
End
68159612/67693929 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/1065412; hsa-mir-11399/Downstream/489589;
Nearest TSS
ENST00000473358/Upstream/8253; ENST00000414904/Downstream/138374;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/7342, chr1-CpG: 89/Downstream/138759
Nearby gene
GADD45A(-5591) ;
Nearest cancer related gene
GADD45A(TSG, -5591) ;
Upstream sequence
CAGACAGCAGAGATTAGACTGGGGAAGGATGAAACTAATTGAATCGAATCTTTTACTTATCCAATAAGTGGGGCAGAGCCTTGGGAAATCTAAAGGAGAC
Downstream sequence
AAAAAACACTCAAGGGAGAATTCTAAGAATTGTCTTCTTTCATCTTAGAACTGGGAAAGTTCTAAGCATCATTGAAAAGTTGATCTTTGTGTCCCTGCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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