VISDB Viral Integration Site DataBase

VIS ID

TVIS10011231

Fusion event

HBV-VTI1A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2322

Orient

+

Integrated sequence

TCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTA| |TCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCA

Chromosome

chr10

Cytoband

q25.2

Reference genome

Start

End

114533048/112773289 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-18a-3p ; hsa-mir-18b-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-6891-3p ; hsa-mir-452-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-302a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-205-5p ; hsa-mir-6793-3p ; hsa-mir-532-5p ; hsa-mir-141-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p

Nearest miRNA

hsa-mir-107/Upstream/139035; hsa-mir-202/Downstream/1004704;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/325727, chr10-CpG: 34/Downstream/176601

Upstream sequence

cacttaacctctttgagacttagttttcttctctctaaggtaggataataataccaagttcctggtcttattgaatcaatcaaaggaagtttttccaagg

Downstream sequence

tttgggaaagcacatagtacctggtacctagtTGCCACACAAAGCATGCATGTTCACACTTATCACACTCCTCTTCCCAACTGTACCATCGATTACACTG