Basic Information
VIS ID
TVIS10011237
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1727
Orient
-
Integrated sequence
GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA| |AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
36382473/36093545 (Hg38)
End
36382473/36093545 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/452293; hsa-mir-107/Downstream/6904018;
Nearest TSS
ENST00000439456/Upstream/4156; ENST00000426283/Downstream/345071;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/328094, chr10-CpG: 51/Downstream/1031672
Nearby gene
FZD8(-452111) ; ANKRD30A(+1032312) ;
Upstream sequence
gactttgcatacattgactgatttttttataacaattgcttgagttagaactattgtttaactacaatcggcctcatttttatagattagaagattgagg
Downstream sequence
cataATTTTCAttgtgagaattaaaagataatttgtttaatgcctagatcatagtaaatactcaaaaatgttagctgtcatcattAGTAGTAGTAATCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate