Basic Information
VIS ID
TVIS10011238
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2490
Orient
+
Integrated sequence
TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG| |GCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAG
Host Sequence
Chromosome
chr10
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
36382484/36093556 (Hg38)
End
36382484/36093556 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/452304; hsa-mir-107/Downstream/6904007;
Nearest TSS
ENST00000439456/Upstream/4167; ENST00000426283/Downstream/345060;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/328105, chr10-CpG: 51/Downstream/1031661
Nearby gene
FZD8(-452122) ; ANKRD30A(+1032301) ;
Upstream sequence
cattgactgatttttttataacaattgcttgagttagaactattgtttaactacaatcggcctcatttttatagattagaagattgaggcataATTTTCA
Downstream sequence
ttgtgagaattaaaagataatttgtttaatgcctagatcatagtaaatactcaaaaatgttagctgtcatcattAGTAGTAGTAATCATAGCTTCTATGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate