Basic Information
VIS ID
TVIS10011242
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2833
Orient
+
Integrated sequence
CCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGG| |GAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCA
Host Sequence
Chromosome
chr11
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
110678022/110807299 (Hg38)
End
110678022/110807299 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/6957319; hsa-let-7a-2/Downstream/540458;
Nearest TSS
ENST00000527297/Upstream/94110; ENST00000635886/Downstream/283069;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/94139, chr11-CpG: 114/Downstream/491280
Nearby gene
ARHGAP20(-94110) ; C11orf53(+448685) ;
Upstream sequence
AAACTTGAACAGGGCCAATACTTGATTTCAGTTGATCCTGCAACATGTTGAGAGCCTAGCCTTGTATCATGGAAACATGATGGGCACCACCTGGATTCCT
Downstream sequence
GTTGGCACTGAGAGGAGGCCAGGAATCACAAGGGTGTTGATCAGGCTTTATGTGGTGGTGAGCCACCAAGGTCCCTGCCTCTAGTTAGAGCTCACGATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate