Basic Information
VIS ID
TVIS10011245
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1855
Orient
+
Integrated sequence
TAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCAT| |GTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTT
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
56793984/57026509 (Hg38)
End
56793984/57026509 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-129-2/Upstream/282528; hsa-let-7a-2/Downstream/614689;
Nearest TSS
ENST00000527297/Upstream/37637; ENST00000497933/Downstream/155238;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1151865, chr11-CpG: 78/Downstream/297888
Nearby gene
OR5AK2(-36666) ; OR5AK4P(+11025) ;
Upstream sequence
AGAACAACACAGGATGAACAATCCTTACATTTTAGTCACTTACAACATTTTTTAAATGATCTCTTCTGAAAAGATTAGCTCTTAATCTGACAGTGATGTG
Downstream sequence
CCAATCAATGTTGTATGTTTTTAGCTCATTTCAGTCCTCAGACACTGAGATCTTTACAAGTCCTATCCCCACAGGCCTCAGAAATAAAATGCCCCATTTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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