Basic Information
VIS ID
TVIS10011246
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1739
Orient
-
Integrated sequence
TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG| |AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTA
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
56794248/57026773 (Hg38)
End
56794248/57026773 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-129-2/Upstream/282792; hsa-let-7a-2/Downstream/614425;
Nearest TSS
ENST00000527297/Upstream/37901; ENST00000497933/Downstream/154974;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1152129, chr11-CpG: 78/Downstream/297624
Nearby gene
OR5AK2(-36930) ; OR5AK4P(+10761) ;
Upstream sequence
CTAAGATGAATCTAATAAAAAGCCTATGTTTTCATAATTAGTTATGCATTTTTGAATATCTGGAGAAAGCAGATGAATAATAAAGAGCATTATACAGAAA
Downstream sequence
CTTTGCCCCATGTCTGGGAAGCACATTGTATGTCTGGAAACACACTAATTCCAAAAAAATTAATTCTGGAAAACTTCGTTAGTAACTGGATTTTCAAAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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