Basic Information
VIS ID
TVIS10011247
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2056
Orient
+
Integrated sequence
TTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACC| |ATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGT
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
6159585/6138355 (Hg38)
End
6159585/6138355 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/2282214; hsa-let-7a-2/Downstream/1096411;
Nearest TSS
ENST00000527297/Upstream/30671; ENST00000311352/Downstream/32053;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1530055, chr11-CpG: 32/Downstream/96183
Nearby gene
OR56B4(-29617) ; OR52B2(+31000) ;
Upstream sequence
gaaaaagacaacaattgaaacatttactagagagattcaaaggcagatttgagcagaaagaaaaattaacaaaccagaagataggacaatataaattact
Downstream sequence
gagtatgagaaacagaaagaaaaaaaattcaagaaaagtgaacatagcctaagggctttgcaggacagcatcaagccaaccaacataaccaaacaacaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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