VISDB Viral Integration Site DataBase

VIS ID

TVIS10011249

Fusion event

HBV-KMT5A integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1766

Orient

-

Integrated sequence

CTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGG| |TCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTT

Chromosome

chr12

Cytoband

q24.31

Reference genome

Start

End

123894802/123410255 (Hg38)

Orient

-

Location type

downstream

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-127-3p ; hsa-mir-502-5p ; hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-7-5p ; hsa-mir-186-5p ; hsa-mir-4716-3p ; hsa-mir-6794-5p ; hsa-mir-218-5p ; hsa-mir-155-5p ; hsa-mir-6734-5p ; hsa-mir-3691-5p ; hsa-mir-3165 ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-6835-5p ; hsa-mir-6716-5p ; hsa-mir-4764-5p ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4530 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6165 ; hsa-mir-3978 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-6813-3p ; hsa-mir-4261 ; hsa-mir-649 ; hsa-mir-194-5p

Nearest miRNA

hsa-let-7i/Upstream/45412; hsa-mir-3612/Downstream/126154;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/20205, chr12-CpG: 65/Downstream/25780

Upstream sequence

atgcattttgagccttagaacaatggcacatagtaagcatcataaactttagctGATGTAATTGTCATTGCGACTTATAATTTACTAGACTTGATGATTC

Downstream sequence

TCAGGAGGCTCTGAATCATCACTGCACCTGTCTTGGGCTGGAAGTCCCTATTACCAGCCCAGATCCCTGTCCCCTCCATGCTTGGGCACTGGTggtagat