Basic Information
VIS ID
TVIS10011250
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2218
Orient
-
Integrated sequence
GGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTT| |CTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTAT
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
157267/48101 (Hg38)
End
157267/48101 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Downstream/1612214;
Nearest TSS
ENST00000546223/Upstream/9968; ENST00000382841/Downstream/18664;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/16442, chr12-CpG: 50/Downstream/18593
Nearby gene
FAM138D(-7855) ; IQSEC3(+18782) ;
Upstream sequence
AGGAACAGAACATCATTTACATATATAAAGAACAGCACGCTGTCTTCTTCCTTGAAGAGGAGCTGGCCCTCCTCCCTGCTTGGCCATCATGCTCAGCCAT
Downstream sequence
GGGCCTGGGCTTGGTTGATGGGAGGGAACAAaaagaatatgggccatctgatcacatggctctggttttgagccccagctgtgctacttagtagctgtgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate