VISDB Viral Integration Site DataBase

VIS ID

TVIS10011252

Fusion event

HBV-EEA1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

988

Orient

+

Integrated sequence

TCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGT| |ATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAG

Chromosome

chr12

Cytoband

q22

Reference genome

Start

End

93199279/92805503 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5682 ; hsa-mir-585-5p ; hsa-mir-3152-3p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-509-3p ; hsa-mir-101-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p

Nearest miRNA

hsa-let-7i/Upstream/6060354; hsa-mir-1178/Downstream/1756286;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/658946, chr12-CpG: 133/Downstream/123063

Upstream sequence

CAACTCTGATGGGTTTTATTTCACCTTTCTGAAGAGGACTTTTCTCAGGTTCTTAGTCTCTACCTTTACTACTGGAACAGTCAAGAGCCCTCATCCCCTT

Downstream sequence

GACACAAGTCAAGTCCATCAACTCAGTCAGAGCAGGTGATTTGATGTTTAAAGACAAAATGTACTCAAATGTAACCAGTTATATGAAGACATTCAAATGA