Basic Information
VIS ID
TVIS10011253
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
697
Orient
+
Integrated sequence
ACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTC| |AGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACC
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
94840/10898 (Hg38)
End
94840/10898 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Downstream/1649417;
Nearest TSS
ENST00000382841/Downstream/27204;
Nearest CpG islands
None/Target, None/Upstream, chr12-CpG: 104/Downstream/19891
Nearby gene
WASH8P(-3577) ; FAM138D(+53106) ;
Upstream sequence
tgcgcctgcgccacgcctcctcccctggacgcgctagcatgtgtctctgcgcctgcgccggcgcggcgcgcctctctgcgcctgcgccggcgcggcgcgc
Downstream sequence
ctctctgcgcctgcgccggcgcggcgcgcctctctgcgcctgcgccggcgcggcgcgcctctctgcgcctgcgccggcgcggcgcgcctctctgcgcctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate