Basic Information
VIS ID
TVIS10011254
Fusion event
HBV-LINC02453 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2012
Orient
+
Integrated sequence
ACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCT| |GTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACC
Host Sequence
Chromosome
chr12
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
98888714/98494936 (Hg38)
End
98888714/98494936 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
LINC02453
Nearest miRNA
hsa-let-7i/Upstream/499488; hsa-mir-1178/Downstream/1694948;
Nearest TSS
ENST00000382841/Upstream/3850; ENST00000548911/Downstream/8919;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/37712, chr12-CpG: 25/Downstream/8890
Upstream sequence
gatttattTTTTTAAATAAGGAGGGAAAGAAAAGACTAAGTGTTAGTCGAGCTGAAGGGAGACAGACTTTTGCCTCTCAGttttttgttttttgcttttt
Downstream sequence
ttttgagacagagcctcgctctgtcgcccaggctggagtgcagtggcgtgatctcggcttactgtaacctacgcctccagggtcccagttcaagcaattc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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