Basic Information
VIS ID
TVIS10011258
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1885
Orient
+
Integrated sequence
TAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCC| |TTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACG
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
72701682/72127544 (Hg38)
End
72701682/72127544 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/5909220; hsa-mir-1267/Downstream/5570468;
Nearest TSS
ENST00000623511/Upstream/260352; ENST00000618209/Downstream/600143;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/259900, chr13-CpG: 91/Downstream/599548
Nearby gene
DACH1(-260352) ; MZT1(+580813) ;
Nearest cancer related gene
DACH1(TSG, -260352) ;
Upstream sequence
AGGCCAGCCCTCAACAGATCAGTCTTGGACAGCTTAACCTGGGCTCTCAGAATTAATTGGAAAAAACGTTCTGAGGTCAAAAATGCTGGAATGCATTAAA
Downstream sequence
GTGGGATTTTACTACAGAATTTTATAAAGCTCTGATTTGCTCATATGAGGACCAATTTTAAAAGACGGAGGTATAATATTGAGAGTTTCCCAAATTATCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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