Basic Information
VIS ID
TVIS10011261
Fusion event
HBV-RAD51B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
773
Orient
+
Integrated sequence
TCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTA| |CAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAA
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
69019658/68552941 (Hg38)
End
69019658/68552941 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/1111011; hsa-mir-1185-1/Downstream/3963879;
Nearest TSS
ENST00000550708/Upstream/7379; ENST00000553944/Downstream/75504;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/877776, chr14-CpG: 40/Downstream/75357
Upstream sequence
aatgctgcacttaaagggataagtaagaggaactgaatcacatgcagcttTTCTAAGGAGAAATGATATTGTTAATATTTTTGCttgttgttctaattat
Downstream sequence
aaaaatactatgtgcttatagtagaaatttcagagtaaagtactaagaataagtaaaaatccctcatactctcatcatcagaagataatcactgtttcta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate