Basic Information
VIS ID
TVIS10011263
Fusion event
HBV-PPP4R3A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2335
Orient
+
Integrated sequence
AGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGG| |AGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATC
Host Sequence
Chromosome
chr14
Cytoband
q32.12
Reference genome
GRCh37/hg19
Start
91937501/91471157 (Hg38)
End
91937501/91471157 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPP4R3A
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-183-5p ; hsa-mir-30d-5p ; hsa-mir-642b-3p ; hsa-mir-4719 ; hsa-mir-642a-3p ; hsa-mir-3613-3p ; hsa-mir-425-5p ; hsa-mir-26b-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-1260a/Upstream/14204867; hsa-mir-1185-1/Downstream/2477069;
Nearest TSS
ENST00000550708/Upstream/4802; ENST00000553427/Downstream/10716;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/52134, chr14-CpG: 164/Downstream/38169
Upstream sequence
AGAACTCAAATTCTAATCAAGTAAAATCTCTTCTATTAACCTAAATATATTAACTTTAGGGAGGAGGAaattagcatttactgaacgcctaacatgtgcc
Downstream sequence
aggaatggtgctttacttttttttatttaattttaacaaccctataagaaactgtttcacattatgagcctattaactaactagacccaagttggaaaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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