Basic Information
VIS ID
TVIS10011269
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
25593545/25582224 (Hg38)
End
25593545/25582224 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA16E
Nearest miRNA
hsa-mir-1225/Upstream/1378993; hsa-mir-11401/Downstream/443013;
Nearest TSS
ENST00000527434/Upstream/158055; ENST00000475436/Downstream/109802;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/323817, chr16-CpG: 138/Downstream/109410
Nearby gene
ZKSCAN2(-324690) ; HS3ST4(+109802) ;
Upstream sequence
aatggcaataaaaagtaatgaagtgctgatgtgtgctatgccatggatgaatcttgaaaacatataccaaatgaaacagtccacttacaaaatatcacat
Downstream sequence
attgtatgactctctttatatggaatgtccagaacaggcaaaactatagagacagaaagtagattagggggttgggtgcagtggctcacacctgtaatcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate