Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011278
Fusion event
HBV-CCDC57 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
244
Orient
-
Integrated sequence
CCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGC| |AGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAAC
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
Start
End
80093939/82136063 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10226/Upstream/442194; hsa-mir-4525/Downstream/100605;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/8606, chr17-CpG: 119/Downstream/76383
Upstream sequence
aattaaaaaaaaccccgacagaaaatagcaagtgctggtgcagatgtggagaaatcagaaccttcgtgcgcagctggtgggcatgggaggcggtttggtg
Downstream sequence
gctccttaccaggttagacacagaattcccacatgacccagcaaggccacttctagggaggcatccaagagaactgaatgttcacagcaatattattcac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.