Basic Information
VIS ID
TVIS10011279
Fusion event
HBV-PRELID3A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
966
Orient
-
Integrated sequence
TCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTA| |ACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTA
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
12427256/12427257 (Hg38)
End
12427256/12427257 (Hg38)
Orient
+
Location type
Exonic
Target gene
PRELID3A
miRNAs that regulate target gene
hsa-mir-615-3p
Nearest miRNA
hsa-mir-3976/Upstream/772316; hsa-mir-1-2/Downstream/1032690;
Nearest TSS
ENST00000575820/Upstream/5971; ENST00000589843/Downstream/5640;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/6393, chr18-CpG: 34/Downstream/3943
Upstream sequence
GGCAGGGCAGACCCTCCTCTCTCTCAGGGCTGGTCAGCCCCTTTTCTTCTTGCTCTTTTGCAGGACCGTGCTCACACAAGAAGCCATCATCACTGTGAAG
Downstream sequence
GGGATTAGCCTTGGTAGTTATTTGGAAAGTTTAATGGCCAATACGATATCATCCAATGCAAAGAAGGTATGTATCTCAATCCTAGGAGTCCTGTGTGTGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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