Basic Information
VIS ID
TVIS10011280
Fusion event
HBV-LOC107985126 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
25167455/27587491 (Hg38)
End
25167455/27587491 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107985126
Nearest miRNA
hsa-mir-1-2/Upstream/995956; hsa-mir-122/Downstream/2711419;
Nearest TSS
ENST00000575820/Upstream/189539; ENST00000423367/Downstream/7544;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/401948, chr18-CpG: 257/Downstream/587959
Nearby gene
CHST9(-402153) ; CDH2(+363475) ;
Upstream sequence
aatttgagaaaacaaatcatgtaaatattctattaataggtttttatgtaatatgttcttgaaaattgtggtaaccctagaaaatattctagttttatat
Downstream sequence
ttaaaaatcagtatcattacctgtactccttaggtttttctgaattcagaacattctaaggtagggaacatctcatctttaacagacatgaataacagag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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