Basic Information
VIS ID
TVIS10011281
Fusion event
HBV-LOC105372112 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2201
Orient
-
Integrated sequence
CTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACT| |CTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGA
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
47212816/49686446 (Hg38)
End
47212816/49686446 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105372112
Nearest miRNA
hsa-mir-1-2/Upstream/199024; hsa-mir-122/Downstream/440053;
Nearest TSS
ENST00000575820/Upstream/97087; ENST00000615535/Downstream/55617;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/124288, chr18-CpG: 60/Downstream/126595
Nearby gene
LIPG(-93538) ; ACAA2(+97058) ;
Upstream sequence
atgttttacacacacagcagattttgaagattttgtgtgaaaaaaatgtaaaatttgattacatgttgaagtgataatattacaaatggattaggttaaa
Downstream sequence
taaaatatattgttaaattaatttaacccactttcttttaatgttctcaaagtgacaatttaaaaactttaaattacaaatatggctcatgttgcatttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate