Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011282
Fusion event
HBV-L3MBTL4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
Start
End
6019812/6019813 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-3976/Upstream/178980; hsa-mir-1-2/Downstream/354548;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/123563, chr18-CpG: 22/Downstream/264562
Nearest cancer related gene
L3MBTL4(TSG, No orient, 0)
Upstream sequence
agatgaaaagctaattagtagcagagctaagtccaaagatggatctTATATTGGCTCCTCACACTTTTAAAGATCAACTCATGTCTTCCAGACAAAGTTA
Downstream sequence
GCCACTcccttttctgtgcaaatttagatcatgtgtgtttctattacagtacttgtgatgtgataattattcatgtttctttctttaaaagtttgtgtcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.