Basic Information
VIS ID
TVIS10011285
Fusion event
HBV-LOC107985179 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
69158360/71491124 (Hg38)
End
69158360/71491124 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107985179
Nearest miRNA
hsa-mir-1-2/Upstream/4409438; hsa-mir-548av/Downstream/1362197;
Nearest TSS
ENST00000575820/Upstream/254022; ENST00000563639/Downstream/87813;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1060264, chr18-CpG: 225/Downstream/1050615
Nearby gene
SOCS6(-1160926) ; LINC01541(+28840) ;
Upstream sequence
TTCTCAGAGGCAAAGCTCTCTGTGTGTCAGATGAAACCGTGAATCAGGAGCAGGAGATGGGAAGAGAACACAAAGTGATGTGTATTTGCATTGGGCTGGG
Downstream sequence
GAGGAGAGCTAGAAAAGGGAGCACTTCATGTAGAAACGAGACCTTCAGGATCCAGGAGAGAGGGAAAACAATAGCAGGCAAGGGAGAGACATGTGCACTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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