Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011289
Fusion event
HBV-PRODH2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2239
Orient
+
Integrated sequence
GCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAG| |AAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGAC
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
Start
End
36289959/35799057 (Hg38)
Orient
-
Location type
downstream
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-10395/Upstream/453430; hsa-let-7e/Downstream/3610566;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/23190, chr19-CpG: 30/Downstream/45035
Upstream sequence
tctcccaaagtgctgggattacaggcatgagtcactgcaccTAGTTTCATTCAATGCTTATTAACTGAGAGAATGGCTTGGCTCTTTCTTCTGTCCCTCC
Downstream sequence
CTCGCCAAGTGGCCTGGGCCGAGCCCCTTGACTTCAGTGCCTTGGTGTCTGCTCCCCATGTGTGCCCTTCCTTTAGGCATCCCCTGGGATGAAGAAAGTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.