Basic Information
VIS ID
TVIS10011295
Fusion event
HBV-MTLN integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2106
Orient
+
Integrated sequence
AGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTA| |GCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGT
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
110969147/110211570 (Hg38)
End
110969147/110211570 (Hg38)
Orient
-
Location type
ncRNA_exonic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
MTLN
Nearest miRNA
hsa-mir-1285-2/Upstream/125047; hsa-mir-10b/Downstream/73283;
Nearest TSS
ENST00000437798/Upstream/6504; ENST00000456683/Downstream/992;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/6516, chr2-CpG: 39/Downstream/705
Upstream sequence
GCAGTAAGGTGCAAGAAAAACATGATACTTCCCCTTATGAAAAAATAAAAGGGTCAAAGATGtttaatttttttattttaaaaataaaattGATTCATAA
Downstream sequence
AGTGCAAGAAGAAGTCATTTCTTTCCGGTAGTCTATATGCATCTTCAACAAGCTGTTAGAAACAGAAAAGAGAAAAAAATTAGAAATACACAATCTGAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate