Basic Information
VIS ID
TVIS10011299
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1854
Orient
+
Integrated sequence
TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA| |TGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGT
Host Sequence
Chromosome
chr2
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
18037361/17856094 (Hg38)
End
18037361/17856094 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2C
Nearest miRNA
hsa-mir-3125/Upstream/5118650; hsa-mir-10b/Downstream/1492335;
Nearest TSS
ENST00000437798/Upstream/39598; ENST00000481414/Downstream/21753;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/101421, chr2-CpG: 18/Downstream/21677
Nearby gene
MSGN1(-38994) ; KCNS3(+22584) ;
Upstream sequence
ggaattcaatataatttttatatgttatgaagtaataCATAAtttttatttcaatagtttttggggaacaggtagcttttggtttcatggtgatatggtt
Downstream sequence
tggctgtatccccacccaaatctcatcttgaattatattacttttgcaccaacttaatagttcccataatccctacgtgtggtgggagggacacagtggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate