Basic Information
VIS ID
TVIS10011309
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1615
Orient
-
Integrated sequence
CGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAG| |ACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAG
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
57429334/57202199 (Hg38)
End
57429334/57202199 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1301/Upstream/1201404; hsa-mir-10b/Downstream/3185163;
Nearest TSS
ENST00000437798/Upstream/1016429; ENST00000463222/Downstream/705452;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1016795, chr2-CpG: 81/Downstream/844308
Nearby gene
CCDC85A(-816025) ; VRK2(+844443) ;
Upstream sequence
ATCTAAATGCTATGTTCCATGGTAAATTTGAGCAGTGCTTTTCAACcctgggaggaaatccagtgtccaagctcaccccagctcagctgaatcagaatca
Downstream sequence
tttggtggtggggtgggggtggcctatgcatcaatactgaaaacaaataaactcaactctgattctaattgcagtcaaggttaagaTATACTTCCCTCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate