VISDB Viral Integration Site DataBase

VIS ID

TVIS10011312

Fusion event

HBV-PLCB4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1642

Orient

-

Integrated sequence

CGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTG| |CCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGT

Chromosome

chr20

Cytoband

p12.2

Reference genome

Start

End

9318725/9338078 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-412-3p ; hsa-mir-371a-3p

Nearest miRNA

hsa-mir-103a-2/Upstream/1966386; hsa-mir-1-1/Downstream/1311558;

Nearest TSS

Nearest CpG islands

None/Target, chr20-CpG: 39/Upstream/268707, chr20-CpG: 32/Downstream/168386

Upstream sequence

CATTGCTGTGTTGTATTCTCTCTCTTCAGGAAGGACAGGTGCTAGAATGCTCCCTCATCAACAGTATTCGGTCGGGAGCCATACCAAAGGTACCTGTGAT

Downstream sequence

TGGTATTTGCTTTTCTAAACACGGATTTACTTATATTGGAAATGGCCATGGCTTCTAGAGATAAAAAACTCACTCTTTGTATCCAGGCTACTTAAAACAT