Basic Information
VIS ID
TVIS10011316
Fusion event
HBV-MRTFA integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
40883322/40487318 (Hg38)
End
40883322/40487318 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
MRTFA
miRNAs that regulate target gene
hsa-mir-183-5p
Nearest miRNA
hsa-mir-1286/Upstream/2498465; hsa-let-7a-3/Downstream/326565;
Nearest TSS
ENST00000624155/Upstream/23884; ENST00000417123/Downstream/34482;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/68220, chr22-CpG: 107/Downstream/148807
Upstream sequence
TAAAATTTTCAAATTAATGTCATAAATATTTATAAGTAATCACTTATTTTGTGTATGCGTTGGTACTAAGTATGACATAGGAACTGAGAAGGAAAACacc
Downstream sequence
actatacatttatataatactttacaaagctactttcatacgtatctcatttgaccctatgagccagaactggagtcattagtcattatacccactacta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate