Basic Information
VIS ID
TVIS10011318
Fusion event
HBV-LOC107986108 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1793
Orient
-
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
Host Sequence
Chromosome
chr3
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
104387607/104668763 (Hg38)
End
104387607/104668763 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986108
Nearest miRNA
hsa-let-7g/Upstream/1144647; hsa-mir-12124/Downstream/4934065;
Nearest TSS
ENST00000440867/Upstream/1994850; ENST00000470756/Downstream/698146;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/2818561, chr3-CpG: 32/Downstream/684922
Nearby gene
MIR548A3(-441502) ; ALCAM(+697950) ;
Upstream sequence
ggaaggcagcgctcactagccctatttgaaaatgaagtctgctcaaccaaaggacggttccaaatgaagaactcgggaatgaagcagctgtgatctcaaa
Downstream sequence
TAGTACAGTTACTCCATAGCATAGTTCAAAGCTACAGAAAAAATAACCATTTACTTTAATAATGTTCTAAAAATACAAACTAATACTCCAGAAGATACAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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