MME _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011322
Fusion event
HBV-MME integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2175
Orient
+
Integrated sequence
AATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACT| |AATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGT
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
154750617/155032828 (Hg38)
End
154750617/155032828 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
MME
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p
Nearest miRNA
hsa-let-7g/Upstream/3466833; hsa-mir-1224/Downstream/4249818;
Nearest TSS
ENST00000440867/Upstream/8704; ENST00000497890/Downstream/46819;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/603652, chr3-CpG: 60/Downstream/46781
Nearby gene
GPR149(-603113) ; MME(+46819) ;
Nearest cancer related gene
MME(TSG, No orient, 0)
Upstream sequence
TGTTTGAATGATCAAAGTGTAAGGAATGGCCAGAGTGACATTAACTTGCAAAGAGCCACACTTTGAGTCTCCACTCTGAGTATTCAGAGTGAGAATCATT
Downstream sequence
aagccaatgttttgaagcacagaagtttggaatcacttatatagacaaagctagagaagtttaacagaatttcaacctctttctatgtaaggcttaatgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate