Basic Information
VIS ID
TVIS10011331
Fusion event
HBV-LINC00504 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2089
Orient
+
Integrated sequence
CTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGG| |GGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAA
Host Sequence
Chromosome
chr4
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
14642041/14640417 (Hg38)
End
14642041/14640417 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LINC00504
Nearest miRNA
hsa-mir-12113/Upstream/1012460; hsa-mir-12115/Downstream/5887858;
Nearest TSS
ENST00000502981/Upstream/231339; ENST00000503926/Downstream/76178;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1012386, chr4-CpG: 31/Downstream/222467
Nearby gene
LINC01085(-500365) ; CPEB2-DT(+269544) ;
Upstream sequence
ctttcttcaggccaaacctctccccagacctccatattcatatattgaactctctactcaacacttccacttggatgcctaaaaagcatctcaaacataa
Downstream sequence
gattactgtggaaaggagcctgaactgctagaggatgagaagtcatgcaagggagactgtggCACTGATGTGAATAGTCTACCAACGTCACCCATGTGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate