Basic Information
VIS ID
TVIS10011337
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1897
Orient
+
Integrated sequence
GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT| |GGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGA
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
191043917/190122762 (Hg38)
End
191043917/190122762 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5184322;
Nearest TSS
ENST00000502981/Upstream/58260; ENST00000616166/Downstream/51012;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/30308, chr4-CpG: 24/Downstream/50371
Nearby gene
DUX4L2(-30441) ;
Upstream sequence
ACTGTTTTAAAAATCATTTTTGACAAGATATTTCTATTTGGGGGATGGAAAAAATGAAGAAACAAATACATTAGAAACAGTCCTCATAGTTAGGAATTAG
Downstream sequence
tagggttagggttagggttagggttgggttagggttggggttggggttggggttggggttggggttgggttagggttagggttagggttagggttagggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate